Effect of Some Immunomodulating Agents on Nitric Oxide Levels
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چکیده
This study evaluated effect of atorvastatin, sitopaladi churna and a decoction of herbs on nitric oxide (NO) levels in rats. Nitric oxide levels in blood were estimated by Cortas &Wakid method. Atorvastatin (10 mg/ kg), sitopaladi churna (1000 mg/ kg), decoction of herbs(10 ml/ kg) containing embelia ribes seeds, cymbopogon citratus(lemon grass), zingiber officinale (ginger), ocimum sanctum(tulsi) increased nitric oxide levels as compared to control (p< 0.05). Atorvastatin, sitopaladi churna, decoction of herbs has shown comparable results with septilin syrup (marketed by The Himalaya Drug Company) which was used as positive control (p>0.05). The study demonstrates that atorvastatin, sitopaladi churna & decoction of herbs increased nitric oxide levels which may mediate their immunostimulant activity.
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